If you prefer the iOS or macOS Safari browser over Chrome or Chromium-based browsers, and you also use Google Docs or Gmail in the browser, you definitely want to enable this feature.
How to enable on macOS Monterey
Click Safari menu → Preferences and choose the Advanced tab, enable “Show Develop in menu bar”:
Chrome has had QUIC (HTTP/3) support for a while already as it benefited Google product users the most since they were the first to roll it out en masse. YouTube via Safari definitely will work faster with HTTP/3 enabled.